The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.
- 1 March 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (3) , 1309-1313
- https://doi.org/10.1073/pnas.75.3.1309
Abstract
Mouse .beta.-globin is encoded in a discontinuous structural gene interrupted by a 550 base pair intervening sequence of DNA. The mature .beta.-globin mRNA appears to be synthesized via a 15S precursor, the length of which roughly equals the total length of the coding and intervening sequences of the .beta.-globin gene. Using the electron microscope to visualize hybrid structures formed between this gene and the purified 15S .beta.-globin mRNA precursor, the intervening sequence is shown to be present within the larger precursor molecule. The precursor mRNA is evidently processed through the removal and rejoining of internal RNA sequences.This publication has 27 references indexed in Scilit:
- The rabbit β-globin gene contains a large insert in the coding sequenceCell, 1977
- Ovalbumin gene is split in chicken DNANature, 1977
- Two adenovirus mRNAs have a common 5′ terminal leader sequence encoded at least 10 kb upstream from their main coding regionsCell, 1977
- An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNACell, 1977
- Globin RNA precursor molecules: Biosynthesis and processing in erythroid cellsCell, 1977
- R loop mapping of the 18S and 28S sequences in the long and short repeating units of drosophila melanogaster rDNACell, 1977
- A novel arrangement of the 18S and 28S sequences in a repeating unit of drosophila melanogaster rDNACell, 1977
- Purification of globin messenger RNA from dimethylsulfoxide-induced friend cells and detection of a putative globin messenger RNA precursorJournal of Molecular Biology, 1976
- A precursor of globin messenger RNAJournal of Molecular Biology, 1976
- A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membraneJournal of Molecular Biology, 1965