Metabolic Relationship Between Acetoacetate and Glucose

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Abstract
Subcut. injn. of Na acetoacetate to rabbits immediately followed by its equimolec-ular amt. of glucose has no effect on the initial blood sugar level of the animals, though individually both cause a considerable increase in the same. Na acetoacetate in gradually increased concn. inhibits glycolysis, in vitro, in the presence of blood. Further, the condensation product of glucose and ethyl acetoacetate (2-tetrahydroxybutyl-5-methyl-4-carbethoxy-furan), admd. subcut. neither affects the initial blood sugar nor the ketonemic levels in rabbits and has no abnormal effect on the urine of the treated animals. The suggestion that immediate rise in the blood sugar, as a result of acetoacetate injn., might be due to a physiol. response has been confirmed and it has been suggested that gradual accumulation of acetoacetate might seriously impair the metabolic relationship between glucose and acetone bodies in a living system.