EFFECTS OF ACTH AND CORTISONE ON LEUKEMIA IN CHILDHOOD

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Abstract
The results of treatment of 14 children with leukemia with ACTH and cortisone have been presented. Complete laboratory and clinical remissions lasting 1 to 33 weeks were induced in six patients; incomplete remissions were induced in two others. No favorable responses were encountered in terminal states, monocytoid leukemia, and granulocytic leukemia differentiated beyond the blast stage. No relationship could be demonstrated between refractoriness to the hormones and to antifolic acid therapy; patients completely refractory to one agent have shown complete response to the other. Although repeated remissions may be induced by hormone therapy, increasing resistance to the drugs tends to develop. While permanent benefit has not been obtained, ACTH and cortisone constitute valuable additions to the therapy of leukemia.
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