METHYLATION ANALYSIS OF CARBOHYDRATE PORTION OF CARCINOEMBRYONIC ANTIGEN

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (6) , 1915-1917
Abstract
The carbohydrate structural units of carcinoembryonic antigen samples isolated from 4 human colon tumors were quantitated using gas chromatography-mass spectrometry after methylation and subsequent conversion to their alditol acetates. Different carcinoembryonic antigen preparations showed some quantitative but no qualitative differences in the structural units present. The results indicate that a large portion of the fucose residues in the glycoprotein were linked to N-acetylglucosamine and most of the branching mannose residues were probably linked to 3 N-acetylglucosamine residues.