PHASE-II STUDY OF LOW-DOSE MITOMYCIN IN PATIENTS WITH OVARIAN-CANCER PREVIOUSLY TREATED WITH CHEMOTHERAPY

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 69  (11) , 1271-1273
Abstract
Forty-three evaluable patients with ovarian cancer who had failed one or more chemotherapy regimens were treated with mitomycin iv at 28-day intervals. Thirty-six patients with good bone marrow reserve received 10 mg/m2 and seven patients with poor bone marrow reserve received 6.7 mg/m2 initially. Ten patients (23%) responded. Patients with an Eastern Cooperative Oncology Group performance status of 0-1 had better response rates and survivals as compared to patients with a performance status of 2-4 (44% vs 8%; median survival, 8 vs 4 months). The acute hematologic and gastrointestinal toxicity was minimal. No patients developed pulmonary, renal, cardiovascular, or local tissue toxicity.