3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone
- 1 December 2005
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 15 (23) , 5197-5201
- https://doi.org/10.1016/j.bmcl.2005.08.091
Abstract
No abstract availableKeywords
This publication has 32 references indexed in Scilit:
- Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced MalignanciesJournal of Clinical Oncology, 2005
- The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitorsBioorganic & Medicinal Chemistry Letters, 2005
- Crystal structures of human HSP90α-complexed with dihydroxyphenylpyrazolesBioorganic & Medicinal Chemistry Letters, 2005
- Heat shock protein 90Current Opinion in Oncology, 2003
- Hsp90 as a therapeutic target in prostate cancerSeminars in Oncology, 2003
- HSP90 as a new therapeutic target for cancer therapy: the story unfoldsExpert Opinion on Biological Therapy, 2002
- Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperoneOncogene, 2000
- Contribution of Intra- and Intermolecular Hydrogen Bonds to the Conformational Stability of Human Lysozyme,Biochemistry, 1999
- Contribution of Buried Hydrogen Bonds to Protein Stability The Crystal Structures of Two Barnase MutantsJournal of Molecular Biology, 1993
- Contribution of hydrogen bonding to the conformational stability of ribonuclease T1Biochemistry, 1992