Processing of Reelin by Embryonic Neurons Is Important for Function in Tissue But Not in Dissociated Cultured Neurons
Open Access
- 18 April 2007
- journal article
- research article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 27 (16) , 4243-4252
- https://doi.org/10.1523/jneurosci.0023-07.2007
Abstract
Reelin, the protein defective in reeler mutant mice, plays a key role during brain development. Reelin is processed proteolytically at two sites, and the central fragment mimics function in vitro.Keywords
This publication has 48 references indexed in Scilit:
- Plasminogen-Mediated Activation and Release of Hepatocyte Growth Factor from Extracellular MatrixAmerican Journal of Respiratory Cell and Molecular Biology, 2006
- Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomographyThe EMBO Journal, 2006
- Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neuronsDevelopment, 2005
- Disabled1 Regulates the Intracellular Trafficking of Reelin ReceptorsJournal of Biological Chemistry, 2005
- Characterization of the various forms of the Reelin protein in the cerebrospinal fluid of normal subjects and in neurological diseasesNeurobiology of Disease, 2004
- Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive HypercholesterolemiaPublished by Elsevier ,2003
- Reelin and brain developmentNature Reviews Neuroscience, 2003
- Plasmin-mediated Release of the Guidance Molecule F-spondin from the Extracellular MatrixJournal of Biological Chemistry, 2001
- A protein related to extracellular matrix proteins deleted in the mouse mutant reelerNature, 1995
- Neocortical histogenesis in normal and reeler mice: A developmental study based upon [3H]thymidine autoradiographyDevelopmental Brain Research, 1982