Nuclear Trafficking
- 28 November 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5650) , 1513-1514
- https://doi.org/10.1126/science.1092863
Abstract
The transcription factor SREBP-2 is a crucial component in cholesterol metabolism, switching on genes that regulate the synthesis and uptake of cholesterol. To activate these genes, SREBP-2 must be transported from the cytoplasm into the nucleus. In his Perspective, Stewart discusses an analysis of the crystal structure of SREBP-2 bound to its nuclear transport protein, importin-, which sheds new light on SREBP-2 nuclear transport ( Lee et al.).Keywords
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