Acute Porphyria and Coproporphyrinuria Following Chloroquine Therapy

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Abstract
The fact that acute intermittent porphyria can be precipitated by various chemicals is well recognized and amply reported in the literature.1-3The chemicals most frequently described as initiating the clinical picture of acute intermittent porphyria are the barbiturates, sulfonmethane (Sulfonal), sulfonethylmethane (Trional), alcohol, and allylisopropylacetylcarbamide (Sedormid). Waldenström4first demonstrated that the barbiturates are capable of precipitating acute attacks of porphyria in individuals having latent porphyria but who were previously free of symptoms. In September, 1954, Linden et al.5reported the case of a patient who had an episode typical of acute intermittent porphyria shortly after receiving chloroquine. This patient was under treatment for six years for chronic discoid lupus erythematosus. Four days after the patient was started on chloroquine therapy, 0.5 gm. daily, he developed chills, low-grade fever, vomiting, and abdominal pain. His urine turned Burgundy red, and tests were positive for uroporphyrin

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