Biased Hypermutagenesis Associated with Mutations in an Untranslated Hairpin of an RNA Virus
Open Access
- 15 July 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (14) , 7813-7817
- https://doi.org/10.1128/jvi.78.14.7813-7817.2004
Abstract
The mutation frequency of Turnip crinkle virus can increase 12-fold without inducing error catastrophe. Lesions in a hairpin repressor frequently reverted and led to second-site alterations biased for specific mutations. These results suggest that the hairpin may also function as an RNA chaperone to properly fold the RNA-dependent RNA polymerase.Keywords
This publication has 22 references indexed in Scilit:
- Repression and Derepression of Minus-Strand Synthesis in a Plus-Strand RNA Virus RepliconJournal of Virology, 2004
- Comparison of Turnip Crinkle Virus RNA-Dependent RNA Polymerase Preparations Expressed in Escherichia coli or Derived from Infected PlantsJournal of Virology, 2002
- Genetic Diversity in RNA Virus Quasispecies Is Controlled by Host-Virus InteractionsJournal of Virology, 2001
- Role of the 3′-Untranslated Regions of Alfalfa Mosaic Virus RNAs in the Formation of a Transiently Expressed Replicase in Plants and in the Assembly of VirionsJournal of Virology, 2001
- Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structureJournal of Molecular Biology, 1999
- RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVALAnnual Review of Microbiology, 1997
- Requirement of a 3′-Terminal Stem-loop inin VitroTranscription by an RNA-dependent RNA PolymeraseJournal of Molecular Biology, 1995
- ???Journal of Molecular Biology, 1995
- Open Reading Frames of Turnip Crinkle Virus Involved in Satellite Symptom Expression and Incompatibility withArabidopsis thalianaEcotype DijonMolecular Plant-Microbe Interactions®, 1995
- Rapid Evolution of RNA GenomesScience, 1982