Between a rock and a hard place?
- 1 March 2006
- journal article
- review article
- Published by Springer Nature in Nature Chemical Biology
- Vol. 2 (3) , 112-118
- https://doi.org/10.1038/nchembio0306-112
Abstract
Developing small-molecule inhibitors against protein-protein interaction targets is among the most difficult challenges in contemporary drug discovery. Recent developments in our understanding of this problem, and in the knowledge and tools available to address it, give cause for renewed hope, but substantial challenges remain.Keywords
This publication has 30 references indexed in Scilit:
- Emerging biologic drugs for the treatment of rheumatoid arthritisAutoimmunity Reviews, 2005
- Protein-Protein Interactions in Drug DiscoveryDrug Design Reviews - Online, 2005
- Small-molecule inhibitors of protein–protein interactions: progressing towards the dreamNature Reviews Drug Discovery, 2004
- Implications of protein flexibility for drug discoveryNature Reviews Drug Discovery, 2003
- Binding of small molecules to an adaptive protein–protein interfaceProceedings of the National Academy of Sciences, 2003
- Integration of NMR and High-Throughput ScreeningCombinatorial Chemistry & High Throughput Screening, 2002
- Inhibition of Protein−Protein Association by Small Molecules: Approaches and ProgressJournal of Medicinal Chemistry, 2002
- Antagonists of protein–protein interactionsChemistry & Biology, 2000
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsAdvanced Drug Delivery Reviews, 1997
- A Hot Spot of Binding Energy in a Hormone-Receptor InterfaceScience, 1995