Synthesis of the spiroacetal unit related to the avermectins and milbemycins
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 1381-1382
- https://doi.org/10.1039/c39840001381
Abstract
A route to enantiomerically pure 1,7-dioxaspiro[5.5]undecanes as important building blocks for milbemycin/avermectin synthesis is described, involving the Wittig reaction of a substituted cyclic ether with aldehydes, followed by spiroacetalisation.Keywords
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