CELL-SURFACE CHANGES IN HELA-CELLS AS AN INDICATION OF CELL-CYCLE EVENTS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (11) , 4044-4051
Abstract
A HeLa cell [human cervical cancer] line synchronized by double thymidine block and mitotic shake off had a characteristic surface morphology for each of the different cell cycle stages. Inhibitors of cell multiplication were used to arrest cells in specific cell cycle phases, and these cells had a surface morphology similar to that of synchronized cells in the same phase. A close association between the cell surface topography and the cycles of DNA synthesis was indicated in the cell nucleus of this HeLa line.