Fluoride Accumulation in Bone and the Effect on Their Physical Properties in Guinea Pigs Given Different Levels of Fluoridated Water

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Abstract
Guinea pigs were exposed to fluoridated water (2-20 ppm) for a period ranging from 15-42 wk. The F- content of the bones increased in proportion to the concentration of F- in drinking water and the period of exposure. The rate constant of accumulation of F- in guinea pig bones was estimated to be 2.5 .times. 10-2 wk-1, with a half-life of plateau formation in the order of 28 wk. This indicated that maximum accumulation of F- during a continuous exposure, or a computed complete elimination of F- after exposure, will take approximately 4 yr. Although fluoridated water improved the weight gain of guinea pigs, no effect on physical properties of bones was observed. No other toxic effects of F- under these conditions were noted.