Administration of Streptomycin in Peanut Oil and Beeswax and in Solvecillin

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Abstract
The absorption and excretion of streptomycin in peanut oil and beeswax and in solvecillin administered by intramusc. injn. were studied. Single doses of streptomycin in 2 ml. of peanut oil and 4% beeswax given to adults produced mild reactions similar to those following injn. of streptomycin in sterile saline soln. Streptomycin was dissolved in 14 ml. of saline soln., added to 3.1 ml. of solvecillin, and emulsified. Single doses of this caused only mild reactions. The blood and urine were collected at intervals for assay purposes. After single injns. of streptomycin (250,000 u.) in peanut oil and beeswax, only 1 or 3 subjects showed a trace of the compd. in serum 1 and 2 hrs. later. The total urinary excretion in 24 hrs. was 3.4 to 7.4% of the initial dose. Similar doses in sterile saline given to 3 subjects showed serum levels of 1.5, 3.0, and 2.5 units/ml., resp., after 6 hrs., with total excretions of 22.0, 24.0, and 48.0% of the amts. given in the 24-hr. urine. The serum levels in 3 subjects 6 hrs. after being given 250,000 u. in solvecillin were 1.5, 2.5, and 1.5 units, resp., and closely similar to the results after injn. of 250,000 u. in 2 cc. of sterile saline soln. The total excretions in the 24-hr. urine varied from 13 to 34% of the streptomycin given.