Possible Agonistic Interaction of Defibrotide, A DNA Derivative, with Adenosine Receptors “In Vitro”
- 1 July 1991
- journal article
- abstracts
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (5) , 1149-1150
- https://doi.org/10.1080/07328319108047258
Abstract
Defibrotide (DFT), a single-stranded DNA, dose-dependently displaced only 3H-CHA and 3H-NECA (markers of adenosine receptors), among 37 radioligands tested. On isolated gastro-intestinal smooth muscle, DFT caused a dose-dependent relaxation, that was antagonized by 8-phenyltheophylline, a mixed Al- and A2-receptor antagonist.Keywords
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