Application of High Pressure Induced by Water-freezing to the Michael Reaction of Alcohols with α,β-Enones
- 1 March 2002
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 31 (3) , 296-297
- https://doi.org/10.1246/cl.2002.296
Abstract
High pressure (about 200 MPa), which was realized by freezing water in a sealed autoclave, has been successfully applied to a high-yield Michael reaction of alcohols and α,β-unsaturated ketones in the presence of a catalytic amount of DMAP and LiClO4. Only a moderate yield was obtained under atmospheric pressure.Keywords
This publication has 7 references indexed in Scilit:
- Effect of high pressure on Michael and Henry reactions between ketones and nitroalkanesNew Journal of Chemistry, 1999
- Microorganism inactivation using high-pressure generation in sealed vessels under sub-zero temperatureApplied Microbiology and Biotechnology, 1998
- The Synthesis and Reactions of Heterocycles under High Pressures: Part IIHETEROCYCLES, 1998
- Practical Formation of γ-Keto or γ-Hydroxy Ether Linkage from Alcohol1Synthetic Communications, 1997
- Efficient Synthesis of Enantiomerically Pure α‐Ionone from (R)‐ and (S)‐α‐DamasconeHelvetica Chimica Acta, 1992
- Asymmetric synthesis of malic acid-type synthons VIA chiral norephedrine-derived oxazolidinesTetrahedron, 1990
- Diastereoselective benzyloxymercuration/demercuration of derivatives of .gamma.-alkyl-.delta.-hydroxy-.alpha.,.beta.-unsaturated esters. A new strategy for the synthesis of aldol-type productsJournal of the American Chemical Society, 1983