A new test system for screening macromolecular antitumor antibiotics and its application to culture fluids of actinomycetes.
- 1 January 1982
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 35 (10) , 1312-1318
- https://doi.org/10.7164/antibiotics.35.1312
Abstract
In searching for macromolecular antitumor antibiotics, a new screening method was developed that consisted of a macromolecular antibiotic detecting system employing macromolecule permeable mutants of Escherichia coli, a system to detect DNA-affecting antibiotics using DNA repair mutants and a mutagenicity detecting system employing a valine resistance test. This new test system was applied to .apprx. 2900 kinds of culture fluids of actinomycetes, and, consequently, 15 samples were found which contained macromolecular antibiotics with DNA affecting properties.This publication has 9 references indexed in Scilit:
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