Determination of Broxaterol in Plasma by Coupled HPLC‐GC

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Abstract
For the analysis of broxaterol 1‐(3‐bromoisoxazol‐5‐yl)‐2‐(tert‐butylamino)ethanol in human plasma and urine an on‐line HPLC‐GC apparatus was used applying the “concurrent solvent evaporation” technique described in previous studies. Broxaterol is quantitatively determined by capillary GC with ECD detection, after extraction from plasma and derivatization. The detection limit of 0.03 ng/ml permits pharmacokinetic studies in man after oral and intravenous administration of the drug.