Chromosomal Abnormalities in Acute Promyelocytic Leukaemia
- 1 January 1981
- journal article
- case report
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 26 (1) , 57-60
- https://doi.org/10.1111/j.1600-0609.1981.tb01624.x
Abstract
In 2 patients with acute promyelocytic leukaemia (APL) an isochromosome for the long arm of chromosome 17 was seen in part of the bone marrow mitoses at diagnosis and relapse, respectively. In one of them, there was a t(15q+;17q‐) affecting one of the No. 15 chromosomes and both arms of the isochromosome. Thus the translocation must have occurred before (or simultaneously with) the formation of the isochromosome. This is the first example of t(15;17) out of 17 patients with APL studied in FinlandKeywords
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