Topical Therapy for Acne

Abstract
There have been major advances in the understanding and treatment of acne in recent years.1 , 2 Since most patients can be successfully managed with topical agents alone, thus avoiding systemic exposure to potentially toxic agents, review of the current approach to topical treatment is warranted. In this brief review, agents are categorized according to their presumed mechanisms of action: sebostatics, comedolytics, exfoliants, bacteriostatics, anhydrotics, and antiinflammatory agents.SebostaticsSebum is a mixture of the products of follicular keratinization and the secretions of the sebaceous gland.3 It has been called the "fuel" of acne because in the anaerobic depths of the sebaceous . . .

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