The Determination of Poldine Methyl Methosulphate in Biological Fluids
- 1 September 1963
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 15 (1) , 100-106
- https://doi.org/10.1111/j.2042-7158.1963.tb12753.x
Abstract
A spectrophotometric method is described for the quantitative determination of the quaternary ammonium compound, poldine methyl methosulphate in aqueous solution and in biological fluids. The method involves coupling with methyl orange with simultaneous extraction into a mixture of ethylene dichloride and isopentanol and the determination of the optical density of the resulting acidified solution. The effect of pH on the coupling and extraction and the specificity of the reaction towards related compounds are examined.Keywords
This publication has 8 references indexed in Scilit:
- Physico-Chemical Studies of (1-Methyl-2-Pyrrolidyl) Methyl Benzilate Methyl Methosulphate: Part I. The Determination of (1-Methyl-2-Pyrrolidyl) Methyl Benzilate Methyl Methosulphate in the Presence of its Breakdown ProductsJournal of Pharmacy and Pharmacology, 1960
- Effect of "Nacton" in Patients with Duodenal UlcerBMJ, 1958
- Colorimetric Estimation of Tertiary and Quaternary AminesAnalytical Chemistry, 1958
- Methods for the Determination of Tral1, a New Anticholinergic Drug**Control Department Abbott Laboratories, North Chicago, Ill.Journal of the American Pharmaceutical Association (Scientific ed.), 1957
- A Long-acting Inhibitor of Gastric SecretionBMJ, 1957
- Colorimetric Method for Quantitative Microdetermination of Quaternary Ammonium CompoundsAnalytical Chemistry, 1954
- THE ESTIMATION OF BASIC ORGANIC COMPOUNDS IN BIOLOGICAL MATERIALPublished by Elsevier ,1947
- THE ESTIMATION OF BASIC ORGANIC COMPOUNDS AND A TECHNIQUE FOR THE APPRAISAL OF SPECIFICITYPublished by Elsevier ,1945