Studies of Human Myoglobin in Several Diseases of Muscle

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Abstract
ALTHOUGH the clinical features, mechanisms of inheritance and classification of various forms of muscular dystrophy are well understood3 4 5 the pathogenesis of these disorders still is unknown. That alterations in the myoglobin content of muscle might be of primary importance in muscular dystrophy first was suggested by Meldolesi6 and later by Biorck,7 who noted that the concentration of myoglobin was low in these disorders. However, neither the properties of the myoglobin in muscle diseases nor the mechanism of the decrease in concentration is known.In the present study myoglobins isolated from several kinds of abnormal muscle have been compared to normal . . .

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