FURTHER STUDIES ON THE EFFECT OF CADMIUM ON THE PROSTATE GLAND—IABSENCE OF PROSTATIC CHANGES IN RATS GIVEN ORAL CADMIUM SULPHATE FOR TWO YEARS

1 February 1975

journal article
Published by Oxford University Press (OUP) in Annals of Work Exposures and Health

Vol. 17, 205-211
https://doi.org/10.1093/annhyg/17.3-4.205

Abstract

Cadmium sulphate (3CdSO₄.8H₂O) was given by gastric instillation to 3 groups of rats. The group most heavily exposed received 0·8 mg 3CdSO₄.8H₂O per kg body weight each week (0·35 mg Cd/kg body wt.) for 2 yr. No macroscopic or microscopic change attributable to treatment was seen in the prostate or any other organ or tissue. The rats used in the experiment were of the CB hooded strain. Males of this strain develop interstitial-cell (Leydig-cell) rumours spontaneously in high incidence (e.g. 80 per cent). Neither regular palpation of the testes nor treatment with cadmium sulphate significantly affected the risk of development of tumours of this kind.

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