Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies
- 25 July 2000
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 55 (2) , 302-304
- https://doi.org/10.1212/wnl.55.2.302
Abstract
Article abstract The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.Keywords
This publication has 9 references indexed in Scilit:
- Alzheimer disease — when and why?Nature Genetics, 1998
- Dementia with Lewy Bodies. A Distinct Non‐Alzheimer Dementia Syndrome?Brain Pathology, 1998
- Mitochondrial DNA Mutations in Alzheimer's DiseaseBiochemical and Biophysical Research Communications, 1997
- Association of the mitochondrial tRNAA4336G mutation with Alzheimer's and Parkinson's diseasesNeuropathology and Applied Neurobiology, 1997
- Association of the mitochondrial tRNAA4336G mutation with Alzheimer's and Parkinson's diseasesNeuropathology and Applied Neurobiology, 1997
- mtDNA Haplotype Analysis in Finnish Families with Leber Hereditary Optic NeuroretinopathyPublished by Wiley ,1997
- Classification of European mtDNAs From an Analysis of Three European PopulationsGenetics, 1996
- No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variantNeuroscience Letters, 1995
- Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease PatientsGenomics, 1993