The Cardiac Auto-Immune System

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Abstract
(1) Rats immunized with rat heart revealed a complex cardiac auto-immune system, similar to that previously seen in the rabbit. Up to 4 cardiac auto-antibodies were seen by two directional immunodiffusion in some animals, while no reactions were seen in control sera. (2) The responses were shown to be true auto-antibodies by reactions of the sera of several individual animals with extracts of their own hearts. (3) As in the rabbit system, several of the antigens involved in these reactions were apparently restricted to cardiac tissue. (4) The rat heart auto-antibodies reacted with analogous proteins in other mammalian hearts (rabbit, human, bovine and guinea pig), as was the case in the rabbit system. (5) Many of the rat anti-rat heart sera revealed antibodies to 2, and perhaps as many as 4 plasma protein allotypes, which exist in the strains of Sprague-Dawley rats used. These plasma allotypes were confirmed by immunization of rats with rat plasma.

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