Multiple quantum NMR spectroscopy methods for measuring the apparent self‐diffusion coefficient of In Vivo lactic acid

Publisher Website
Google Scholar
Abstract
Nuclear magnetic resonance spectroscopy methods are presented for measuring the apparent self‐diffusion coefficient of lactic acid in vivo. These techniques incorporate diffusion‐sensitive gradients into multiple quantum NMR pulse sequences that are employed for spectral editing. Both diffusion‐sensitive zero quantum (ZQ) and double quantum (DQ) spectral editing techniques have been developed and the DQ method has been used to measure the apparent self‐diffusion coefficient of in vivo lactic acid in H‐MESO‐1 human tumor xenografts subcutaneously implanted in athymic mice.