DNA Repair and Survival in Lung Cancer — The Two Faces of Janus

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Abstract
Lung cancer, the most common cause of cancer deaths globally, results in about 1 million deaths each year. Despite advances in treatment over the past two decades, the improvement in long-term survival has been limited: only about 15% of patients survive for 5 years or longer. The high mortality is due mainly to early and widespread dissemination of the cancer, which means that surgical removal of early-stage non–small-cell lung cancer results in the best chance for long-term survival. Chemotherapy for advanced non–small-cell lung cancer (which accounts for about 85% of all lung cancers) or as adjuvant treatment for patients with . . .