The Acquisition of a Memory Phenotype by Murine CD4+ T Cells Is Accompanied by a Loss in Their Capacity to Increase Intracellular Calcium
Open Access
- 1 January 1992
- journal article
- research article
- Published by Wiley in Clinical and Developmental Immunology
- Vol. 3 (1) , 25-34
- https://doi.org/10.1155/1992/31573
Abstract
During the process of aging, the fraction of CD4+ T Cells with a naive phenotype, that is, Pgp‐1- CD45RBHighMEL‐14+, decreases in favor of CD4+ T memory cells. Total CD4+ T cells from aged mice displayed a diminished calcium response to anti‐CD3 and even ionomycin as compared to the cells from young mice, and this was related to the changed composition of the CD4+ T‐cell population. Regardless the age of the donor mice, naive CD4+ T cells effectively increased intracellular calcium, whereas memory CD4+ T cells were impaired in this regard. In addition, a heterogeneity in the differentiation stage of the naive CD4+ T cells was shown by the observation that calcium mobilization in naive CD4+ T cells from young mice was more profound than that in their aged counterparts. These data thus indicate that during the acquisition of a memory phenotype, murine CD4+ T cells lose the capacity to increase intracellular calcium, which in turn may be responsible for the decreased level of IL‐2 production by these cells.Keywords
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