Urticaria Pigmentosa as a Systemic Disease

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Abstract
Clinical roentgenologic and histochemical investigations of recent years have helped to throw some light on the nature of urticaria pigmentosa. Observations in ever-increasing number indicate that the disease cannot be regarded any more as a purely cutaneous one, but it may affect other organs of the body. The most important of these observations is that of Ellis1 who at an autopsy of a one-year-old child (the first and so far the only autopsy performed in a case of this disease) found mast cells in practically all the reticuloendothelial system. The mast cells undoubtedly comprise the histopathological basis of urticaria pigmentosa, and Sézary,2 therefore, suggested for it the name mastocytosis, a much more suitable name than urticaria pigmentosa because urticaria is almost always entirely lacking and sometimes the pigmentation too. The mast cells were discovered by Ehrlich. Using toluidine blue he differentiated them from other

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