From available literature, it would seem that generalized congenital hyperkeratoses have been recognized and recorded from early times. For many years, unquestionably, certain of the cases reported under the caption "ichthyosis congenita" included not only this condition as we now know it, but also cases which more recent study has identified as separate clinical entities. In view of these more exact classifications, the following case, presenting mixed characteristics and complications not ordinarily associated with ichthyosis congenita, and, finally, affording the opportunity of necropsy study, would seem to merit a somewhat detailed report. REPORT OF CASE History.— The mother of the patient, who presented herself at the Salvation Army White Shield Home, April 5, 1923, and was assigned to the service of Drs. Sheldon and Patrick, was a girl aged 18, obviously low in the intellectual scale. She could give no especially satisfactory history. She said that she was of American