A ferriprotoporphyrin IX‐chloroquine complex promotes membrane phospholipid peroxidation A possible mechanism for antimalarial action

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Abstract
The effect of a ferriprotoporphyrin IX ‐chloroquine complex on phospholipid membranes was investigated on the basis of iron‐induced lipid peroxidation using microsomal phospholipid liposomes. The ferriprotoporphyrin IX ‐chloroquine complex remarkably promoted peroxidative cleavage of unsaturated phospholipids in liposomes, compared with ferriprotoporphyrin IX alone. Neither the combination of protoporphyrin IX with chloroquine nor the combination of Fe 3+‐ADP with chloroquine promoted lipid peroxidation. DL‐α‐Tocopherol completely inhibited lipid peroxidation induced by the ferriprotoporphyrin IX ‐chloroquine complex.