Biological Relevance of Gamma-ray-induced Alkali-labile Sites in Single-stranded DNA in Aqueous Solutions
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 30 (3) , 223-228
- https://doi.org/10.1080/09553007614551001
Abstract
Gamma-irradiation of single-stranded ϕX174 DNA in aqueous solution in the presence of oxygen produces at least two types of alkali-labile site. One is lethal and gives rise to single-strand breaks by treatment with alkali. The other is non-lethal, but is converted to lethal damage by alkali. The effect of alkali is dependent on temperature. This dependence is different for both types of alkali-labile site.This publication has 10 references indexed in Scilit:
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