Thermal Enhancement of Thio-TEPA Cytotoxicity2

Publisher Website
Google Scholar
Abstract
The relationship between temperature and cytotoxicity of tris(1-aziridinyl)-phosphine sulfide (thio-TEPA) was measured in vitro with the inactivation of clone-forming hamster cells used as an end point. Under the conditions of these experiments, the rate of cell inactivation was doubled by twice the concentration of the alkylating agent in the medium. However, it was also doubled, without an increase in thio-TEPA concentration, simply by raising the incubation temperature from 37 to 40° C. Increasing the temperature to 45° C accelerated cell inactivation to 15 times that at 37° C. These data suggest that the effects of an alkylating agent may be enhanced in a selected organ or tissue by localized microwave heating during systemic chemotherapy.

This publication has 0 references indexed in Scilit: