Different biochemical composition of connective tissue in continent and stress incontinent women
- 11 January 1987
- journal article
- research article
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 66 (5) , 455-457
- https://doi.org/10.3109/00016348709022054
Abstract
The collagen content in biopsies from skin and ligamentum rotundum of 7 women with a long history of stress incontinence was compared with that of continent controls. The collagen was extracted with 0.5 M acetic acid, followed by digestion with pepsin and quantitated as hydroxyproline. The skin of stress incontinent women contained 40% less collagen than that of continent women. The findings for ligamentum rotundum were similar. These results suggest a deteriorated connective tissue in stress‐incontinent women and cast new light on the etiology of the diseaseKeywords
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