Different effects of glucagon and epinephrine on the kinetic properties of liver glycogen synthase
- 10 January 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 151 (1) , 76-78
- https://doi.org/10.1016/0014-5793(83)80346-9
Abstract
Kinetic constants of glygocen synthase (S 0.5 for glucose-6-P and M 0.5 for UDP-glucose) were determined after hepatocytes isolated from starved rats were incubated with either glucagon or epinephrine. Incubation with these hormones resulted in an increase in both S 0.5 and M 0.5. However, the action of glucagon resulted in great modifications on S 0.5 whereas epinephrine affected mainly M 0.5. Therefore, glucagon and epinephrine alter the kinetic properties of glycogen synthase provoke the phosphorylation of glycogen synthase at different site(s) acting through different mechanisms.Keywords
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