THE NITROREDUCTION OF CHLORAMPHENICOL BY HUMAN-LIVER TISSUE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 97  (6) , 881-886
Abstract
Fresh-frozen human liver tissue was assayed for its ability to reduce the nitro group of R.sbd.NO2 [chloramphenicol] to the amine. The livers (10) exhibited reductase activity. The reduction was potentiated by NADPH and abolished by boiling the liver homogenates. Nitroreductase activity varied among the different livers by as much as severalfold. The findings showed the ability of the human liver to reduce R.sbd.NO2, and supported the hypothesis that certain toxic intermediates of the nitro reduction of R.sbd.NO2 may be responsible for the aplastic anemia associated with this drug.

This publication has 0 references indexed in Scilit: