THE EFFECTS OF LOW DOSES OF CYPROTERONE ACETATE ON SOME FUNCTIONS OF THE REPRODUCTIVE SYSTEM IN NORMAL MEN

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Abstract
One daily dose of either 5 mg or 10 mg cyproterone acetate (CA) was administered to 2 groups of 4 fertile men for 6 mo. The medication was preceded by a 3 mo. placebo period and followed by a recovery phase of 5-8 mo. During CA-treatment the sperm count/ml decreased and the percentage of abnormal spermatozoa increased slightly (0.001 < P < 0.05). Sperm penetration assessed by the Kremer test did not show any decrease during treatment. Serum levels of testosterone and FSH [follitropin] decreased, but those of LH [lutropin] remained unchanged during treatment. Two pregnancies occurred after 1 3/4 and 5 1/2 mo. of CA-treatment. The serum-CA concentration in these 2 volunteers did not differ from that of the remainder. Three subjects who began the study were withdrawn because of depressive mood changes and weakness combined with dizziness. Data from these subjects were not included. Daily doses of 5 mg and 10 mg of cyproterone acetate are not effective as a male contraceptive.