INFLUENCE OF METHYLTESTOSTERONE AND CYPROTERONE ACETATE ON WOLFFIAN DUCT DIFFERENTIATION IN FEMALE RAT FOETUSES

Abstract
SUMMARY In contrast to results in rabbit and dog foetuses, Wolffian duct stabilization in male rat foetuses was inhibited by cyproterone acetate. On the other hand, the stabilizing effect of methyltestosterone in female rat foetuses could be abolished even when excessive androgen doses were given. The hormonal factor(s) involved in normal Wolffian duct stabilization in male rat foetuses remains to be clarified.

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