Factors Characterizing Staphylococcus epidermidis Invasiveness Determined by Comparative Genomics
Open Access
- 1 March 2005
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (3) , 1856-1860
- https://doi.org/10.1128/iai.73.3.1856-1860.2005
Abstract
Virulence mechanisms of the leading nosocomial pathogen Staphylococcus epidermidis are poorly understood. We used microarray-based genome-wide comparison of clinical and commensal S. epidermidis strains to identify putative virulence determinants. Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis, and potential targets for drug development against S. epidermidis infections.Keywords
This publication has 27 references indexed in Scilit:
- Genomewide Analysis of Gene Expression inStaphylococcus epidermidisBiofilms: Insights into the Pathophysiology ofS. epidermidisBiofilms and the Role of Phenol‐Soluble Modulins in Formation of BiofilmsThe Journal of Infectious Diseases, 2005
- The Bacterial Insertion Sequence Element IS 256 Occurs Preferentially in Nosocomial Staphylococcus epidermidis Isolates: Association with Biofilm Formation and Resistance to AminoglycosidesInfection and Immunity, 2004
- Normally FunctioningmurFIs Essential for the Optimal Expression of Methicillin Resistance inStaphylococcus aureusMicrobial Drug Resistance, 2003
- NaCl-sensitive mutant ofStaphylococcus aureushas a Tn917-lacZinsertion in itsarsoperonFEMS Microbiology Letters, 2003
- Characterization of the Importance ofStaphylococcus epidermidisAutolysin and Polysaccharide Intercellular Adhesin in the Pathogenesis of Intravascular Catheter–Associated Infection in a Rat ModelThe Journal of Infectious Diseases, 2001
- Identification of a novel antigen fromStaphylococcus epidermidisFEMS Immunology & Medical Microbiology, 2000
- Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell WallScience, 1999
- Molecular basis of intercellular adhesion in the biofilm‐forming Staphylococcus epidermidisMolecular Microbiology, 1996
- Cloning and nucleotide sequence of the signal peptidase II (lsp)-gene fromStaphylococcus carnosusFEMS Microbiology Letters, 1995
- MSCRAMM-MEDIATED ADHERENCE OF MICROORGANISMS TO HOST TISSUESAnnual Review of Microbiology, 1994