Rapid thymomas induced by Abelson murine leukemia virus.

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Abstract
Abelson murine leukemia virus (A-MuLV) is derived from the thymotropic Moloney leukemia virus. Injection of mice with A-MuLV by conventional routes results in rapidly arising peripheral and bone marrow lymphomas, not thymomas or T cell tumors. Thymomas were induced by intrathymic injection of A-MuLV into BALB/c and C57BL/Ka mice. In both strains thymomas arose with short latent periods, comparable with the latencies of nonthymic tumors induced by i.p. injection of A-MuLV and significantly shorter than those of thymomas induced by intrathymic injection of Moloney leukemia virus. Cells of the BALB/c thymomas were predominantly Thy-1-; those of C57BL/Ka thymomas were predominantly Thy-1+. Tissue culture lines were established and cloned. Some of these expressed low amounts of Thy-1 and 1 also expressed Lyt-1. Virus from cloned lines transformed 3T3 cells in vitro and induced Abelson disease in vivo when injected i.p. into neonates. The A-MuLV p120 protein was precipitated from metabolically labeled cell lysates of 1 cloned Thy-1+ line. Thus, A-MuLV can transform cells in the T lymphocyte lineage.