Primary Aldosteronism with Bilateral Multiple Aldosterone-Producing Adrenal Adenomas.
Open Access
- 1 January 1996
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 35 (12) , 970-975
- https://doi.org/10.2169/internalmedicine.35.970
Abstract
A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA). She was suspected to have idiopathic hyperaldosteronism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed "paradoxical hyperplasia". This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.(Internal Medicine 35: 970-975, 1996)Keywords
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