The Case for Routine Childhood Vaccination against Hepatitis A

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Abstract
Although its incidence has declined in the past decade, hepatitis A is still responsible for nearly 60 percent of the cases of acute viral hepatitis in the United States. In about half these cases, no source of infection is identified. The investigation of a far-flung, foodborne outbreak of hepatitis A from a common source described by Hutin et al. in this issue of the Journal 1 is a superb example of “shoe-leather” epidemiology combined with molecular sequencing to establish the genetic relatedness of hepatitis A virus (HAV) isolates. Classic case–control and cohort studies of food consumed during the probable period of . . .