Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis
- 1 January 2007
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 75 (1) , 527-530
- https://doi.org/10.1128/iai.00732-06
Abstract
Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.Keywords
This publication has 15 references indexed in Scilit:
- Mycobacterium tuberculosis Complex and Mycobacterial Heat Shock Proteins in Lymph Node Tissue from Patients with Pulmonary SarcoidosisJournal of Clinical Microbiology, 2006
- Molecular Analysis of Sarcoidosis Tissues forMycobacteriumSpecies DNAEmerging Infectious Diseases, 2002
- Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis-Infected Individuals: Associations with Clinical Disease State and Effect of TreatmentThe Journal of Immunology, 2001
- High frequencies of circulating IFN-γ-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restrictedMycobacterium tuberculosis epitope inM. tuberculosis-infected subjects without diseaseEuropean Journal of Immunology, 2000
- SarcoidosisNew England Journal of Medicine, 1997
- Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosisJournal of Bacteriology, 1993
- An inhibitor of the toxicity of tumour necrosis factor in the serum of patients with sarcoidosis, tuberculosis and Crohn's diseaseClinical and Experimental Immunology, 1990
- Spontaneous release of interleukin 2 by lung T lymphocytes in active pulmonary sarcoidosis is primarily from the Leu3+DR+ T cell subset.Journal of Clinical Investigation, 1986
- Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis.Journal of Clinical Investigation, 1985
- Sarcoidosis: histopathological definition and clinical diagnosis.Journal of Clinical Pathology, 1977