Efficient total synthesis of racemic and optically active cyclobut-A and simple analogues
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 7,p. 589-591
- https://doi.org/10.1039/c39930000589
Abstract
Rapid synthesis of the potent antiviral agent, cyclobut-A, 1a, from the inexpensive starting materials maleic anhydride and acetylene, in both racemic and optically active forms, is described; the route also allows for the preparation of several hydroxylated and keto analogues in good overall yield.Keywords
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