Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives.

1 January 1995

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 48 (12) , 1467-1480
https://doi.org/10.7164/antibiotics.48.1467

Abstract

New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.

Keywords

SYNTHETIC SPICAMYCIN
SPICAMYCIN DERIVATIVES
SEMI SYNTHETIC
STRUCTURE ANTITUMOR
ANTITUMOR ACTIVITY RELATIONSHIP

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