Prolonged intraesophageal pH monitoring with 16-Hr overnight recording

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Abstract
From studies in 43 patients (17 male, 26 female, mean age 51 years), we compared the analysis of the routine complete “24-hr” ambulatory esophageal pH monitoring study to that of the 16-hr overnight interval (4∶00pm to 8∶00am). The latter included a major meal with an upright postprandial period and a recumbent period. All patients were monitored for at least 20 hr (median=22.6 hr). The percent distal esophageal pHP6.0% upright; >1.2% recumbent). Based on this, sensitivity and specificity for 16-hr monitoring were as follows: total study: 86% and 95%; upright: 80% and 91%; recumbent: 100% for both. Conclusions: (1) a 16-hr overnight pH monitoring period can provide a reliable representation of “24-hr” distal esophageal acid exposure, (2) this shorter monitoring may improve patient acceptability and compliance, and (3) the symptom index was changed in 26.3% of patients using the 16-hr evaluation.