Structure of Ristocetin A
- 1 September 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (9) , 2420-2421
- https://doi.org/10.1073/pnas.69.9.2420
Abstract
Acid hydrolysis of ristocein A yields a number of amino acids of unusual structure. One set of diastereoisomeric pairs has a molecular weight of 362 and an empirical formula of C 17 H 18 N 2 O 7 . Mass spectral and nuclear magnetic resonance (NMR) evidence suggest a diphenyl ether with hydroxyl and α-amino acid [-CH-(NH 2 )COOH] groups on one ring, and methyl, hydroxyl and α-amino acid groups on the other ring. Coupling in the NMR and nuclear Overhauser effect experiments favor certain substitution patterns, which are shown. Another set of diastereoisomers seems to be a lower homolog of the previous set, without the aromatic methyl group.Keywords
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