Exercise-induced enhancement of lipid peroxide metabolism in tissues and their transference into the brain in rat.

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Abstract
This study was conducted to investigate whether a moderate running exercise would enhance or prevent the lipid peroxidation in animal body and also stimulate or depress the degradation-excretion of lipid peroxides (LIPOX, thiobarbituric acid reactive substances determined as malon dialdehyde) in young female rats. Compared with sedentary rats, voluntary wheel-running exercised rats did not show any significant difference in total LIPOX contents in plasma and several tissues including brain, and whole body during 4 weeks of experiment with a vitamin E-free low LIPOX diet. When rats were previously fed a high LIPOX diet and then allowed voluntary exercise with a vitamin E-added low LIPOX diet, total LIPOX contents per whole body reduced significantly faster in the exercised rats than in the sedentary controls. At that period, LIPOX were progressively increased in the brain in both groups of animals, but was significantly greater in the exercised group. Interestingly, > 80% of total LIPOX contents in whole body were stored in carcass portions regardless of greater or lesser amounts of LIPOX contents in rats. Moderate exercise for several weeks might enhance the degradation-excretion of LIPOX but not the formation-accumulation of LIPOX in rats. Exercise also seems to modulate LIPOX transference among tissues.