Nucleophilic addition to 4,5-dihydroimidazoles: a ketone synthesis via tetrahydrofolate coenzyme models
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 1995-1998
- https://doi.org/10.1039/p19860001995
Abstract
1-Benzyl-2-alkyl-3-methyl-4,5-dihydroimidazolium salts with Grignard reagents give addition products that are hydrolysed to ketones; 4,5-dihydroimidazoles and 4,5-dihydroimidazolium salts with hydride reagents afford N-alkylated ethane-1,2-diamines.This publication has 3 references indexed in Scilit:
- Dihydroimidazoles in synthesis: C-alkylation of 1-benzyl-2-(α-lithioalkyl)-4,5-dihydroimidazoles and a synthesis of alkanoic acidsJournal of the Chemical Society, Perkin Transactions 1, 1985
- Models of folate coenzymes—VIITetrahedron, 1983
- Über C‐substituierte Piperazinderivate Untersuchungen über Synthetische Arzneimittel, 10. MitteilungHelvetica Chimica Acta, 1962